Oral type 1 interferon protection from lethal influenza virus
نویسندگان
چکیده
* Author for correspondence: Head of Discipline, Discipline of Microbiology and Immunology, M502 School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Australia. Tel: (08) 9346 2217, Fax: (08) 9346 2912, Email: [email protected]. Abstract. The persistence of highly pathogenic avian influenza virus within wild bird populations has forged interest in control measures to limit a possible human pandemic. We have identified an optimal low oral dose of IFN-α that when delivered daily as prophylactic therapy protects C57BL/6J mice from a lethal challenge with mouse adapted human influenza virus A/PR/8/34 H1N1. These results provide strong support for the application of low dose type 1 IFN pretreatment to human influenza control. Additionally, recent data suggests that low dose oral IFNαA treatment of influenza causes the recruitment of Regulatory T cells from the spleen to the site of inflammation; this response may form the basis of the observed protection from lethal infection.
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